Epistasis shapes the fitness landscape of an allosteric specificity switch

Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a computationally redesigned ligand-inducible allosteric tra...

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Autores principales: Kyle K. Nishikawa, Nicholas Hoppe, Robert Smith, Craig Bingman, Srivatsan Raman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/40550d62365e4883ad8995105966c5fc
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