Epistasis shapes the fitness landscape of an allosteric specificity switch

Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a computationally redesigned ligand-inducible allosteric tra...

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Autores principales:	Kyle K. Nishikawa, Nicholas Hoppe, Robert Smith, Craig Bingman, Srivatsan Raman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/40550d62365e4883ad8995105966c5fc
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id	oai:doaj.org-article:40550d62365e4883ad8995105966c5fc
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spelling	oai:doaj.org-article:40550d62365e4883ad8995105966c5fc2021-12-02T17:27:12ZEpistasis shapes the fitness landscape of an allosteric specificity switch10.1038/s41467-021-25826-72041-1723https://doaj.org/article/40550d62365e4883ad8995105966c5fc2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25826-7https://doaj.org/toc/2041-1723Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a computationally redesigned ligand-inducible allosteric transcription factor and found that epistasis creates distinct biophysical and biological functional landscapes.Kyle K. NishikawaNicholas HoppeRobert SmithCraig BingmanSrivatsan RamanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyle K. Nishikawa Nicholas Hoppe Robert Smith Craig Bingman Srivatsan Raman Epistasis shapes the fitness landscape of an allosteric specificity switch
description	Epistasis plays an important role in the evolution of novel protein functions because it determines the mutational path a protein takes. Here, the authors combine functional, structural and biophysical analyses to characterize epistasis in a computationally redesigned ligand-inducible allosteric transcription factor and found that epistasis creates distinct biophysical and biological functional landscapes.
format	article
author	Kyle K. Nishikawa Nicholas Hoppe Robert Smith Craig Bingman Srivatsan Raman
author_facet	Kyle K. Nishikawa Nicholas Hoppe Robert Smith Craig Bingman Srivatsan Raman
author_sort	Kyle K. Nishikawa
title	Epistasis shapes the fitness landscape of an allosteric specificity switch
title_short	Epistasis shapes the fitness landscape of an allosteric specificity switch
title_full	Epistasis shapes the fitness landscape of an allosteric specificity switch
title_fullStr	Epistasis shapes the fitness landscape of an allosteric specificity switch
title_full_unstemmed	Epistasis shapes the fitness landscape of an allosteric specificity switch
title_sort	epistasis shapes the fitness landscape of an allosteric specificity switch
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40550d62365e4883ad8995105966c5fc
work_keys_str_mv	AT kyleknishikawa epistasisshapesthefitnesslandscapeofanallostericspecificityswitch AT nicholashoppe epistasisshapesthefitnesslandscapeofanallostericspecificityswitch AT robertsmith epistasisshapesthefitnesslandscapeofanallostericspecificityswitch AT craigbingman epistasisshapesthefitnesslandscapeofanallostericspecificityswitch AT srivatsanraman epistasisshapesthefitnesslandscapeofanallostericspecificityswitch
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Epistasis shapes the fitness landscape of an allosteric specificity switch

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