A Novel Small-Molecule Inhibitor of the <italic toggle="yes">Mycobacterium tuberculosis</italic> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

A Novel Small-Molecule Inhibitor of the <italic toggle="yes">Mycobacterium tuberculosis</italic> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

ABSTRACT Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters” that are difficult to kill using conventional anti-TB...

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Autores principales: Paridhi Sukheja, Pradeep Kumar, Nisha Mittal, Shao-Gang Li, Eric Singleton, Riccardo Russo, Alexander L. Perryman, Riju Shrestha, Divya Awasthi, Seema Husain, Patricia Soteropoulos, Roman Brukh, Nancy Connell, Joel S. Freundlich, David Alland
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/4063dfd78f48410f8cdd22b4c8e25ff7
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