A Novel Small-Molecule Inhibitor of the <italic toggle="yes">Mycobacterium tuberculosis</italic> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

QR Code

A Novel Small-Molecule Inhibitor of the <italic toggle="yes">Mycobacterium tuberculosis</italic> Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells

ABSTRACT Active tuberculosis (TB) and latent Mycobacterium tuberculosis infection both require lengthy treatments to achieve durable cures. This problem has partly been attributable to the existence of nonreplicating M. tuberculosis “persisters” that are difficult to kill using conventional anti-TB...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Paridhi Sukheja, Pradeep Kumar, Nisha Mittal, Shao-Gang Li, Eric Singleton, Riccardo Russo, Alexander L. Perryman, Riju Shrestha, Divya Awasthi, Seema Husain, Patricia Soteropoulos, Roman Brukh, Nancy Connell, Joel S. Freundlich, David Alland
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2017
Sujets:	Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/4063dfd78f48410f8cdd22b4c8e25ff7
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Synergistic Lethality of a Binary Inhibitor of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> KasA
par: Pradeep Kumar, et autres
Publié: (2018)

Development, Interlaboratory Evaluations, and Application of a Simple, High-Throughput <italic toggle="yes">Shigella</italic> Serum Bactericidal Assay
par: Moon H. Nahm, et autres
Publié: (2018)

Wang Meng y la nueva narrativa china
par: Flora Botton Beja
Publié: (1984)

Identification of a <italic toggle="yes">Pseudomonas aeruginosa</italic> PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles
par: Sebastian Doberenz, et autres
Publié: (2017)

Cytochrome <italic toggle="yes">bd</italic>-Dependent Bioenergetics and Antinitrosative Defenses in <italic toggle="yes">Salmonella</italic> Pathogenesis
par: Jessica Jones-Carson, et autres
Publié: (2016)

The mRNA Cap 2′-<italic toggle="yes">O</italic>-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes
par: Graham D. Williams, et autres
Publié: (2020)

Structure of the Recombinant <italic toggle="yes">Neisseria gonorrhoeae</italic> Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci
par: Hannia Liliana Almonacid-Mendoza, et autres
Publié: (2018)

Typhoon Inversion Method Combined With the YanMeng Wind Field and a Meteorological Monitoring System for Transmission Lines
par: Liqiang An, et autres
Publié: (2021)

Nontypeable <named-content content-type="genus-species">Haemophilus influenzae</named-content> Lipooligosaccharide Expresses a Terminal Ketodeoxyoctanoate <italic toggle="yes">In Vivo</italic>, Which Can Be Used as a Target for Bactericidal Antibody
par: Michael A. Apicella, et autres
Publié: (2018)

A Mechanosensitive Channel Governs Lipid Flippase-Mediated Echinocandin Resistance in <named-content content-type="genus-species">Cryptococcus neoformans</named-content>
par: Chengjun Cao, et autres
Publié: (2019)

Non-Toxin-Producing <italic toggle="yes">Bacillus cereus</italic> Strains Belonging to the <italic toggle="yes">B. anthracis</italic> Clade Isolated from the International Space Station
par: Kasthuri Venkateswaran, et autres
Publié: (2017)

Microevolution of Serial Clinical Isolates of <italic toggle="yes">Cryptococcus neoformans</italic> var. <italic toggle="yes">grubii</italic> and <italic toggle="yes">C. gattii</italic>
par: Yuan Chen, et autres
Publié: (2017)

Long-Term <italic toggle="yes">In Vitro</italic> Culture of the Syphilis Spirochete <italic toggle="yes">Treponema pallidum</italic> subsp. <italic toggle="yes">pallidum</italic>
par: Diane G. Edmondson, et autres
Publié: (2018)

SuDaMa: <italic>Su</italic>stainable Open Government <italic>Da</italic>ta <italic>Ma</italic>nagement Framework for Long-Term Publishing and Consumption
par: Elena Sanchez-Nielsen, et autres
Publié: (2021)

RNA Viruses in <italic toggle="yes">Blechomonas</italic> (Trypanosomatidae) and Evolution of <italic toggle="yes">Leishmaniavirus</italic>
par: Danyil Grybchuk, et autres
Publié: (2018)

IS<italic toggle="yes">26</italic>-Mediated Precise Excision of the IS<italic toggle="yes">26</italic>-<italic toggle="yes">aphA1a</italic> Translocatable Unit
par: Christopher J. Harmer, et autres
Publié: (2015)

Evidence for a Structural Role for Acid-Fast Lipids in Oocyst Walls of <italic toggle="yes">Cryptosporidium</italic>, <italic toggle="yes">Toxoplasma</italic>, and <italic toggle="yes">Eimeria</italic>
par: G. Guy Bushkin, et autres
Publié: (2013)

What's in a Name? IS<italic toggle="yes">Swi1</italic> Corresponds to Transposons Related to Tn<italic toggle="yes">2</italic> and Tn<italic toggle="yes">3</italic>
par: Sally R. Partridge
Publié: (2015)

IS<italic toggle="yes">26</italic> Family Members IS<italic toggle="yes">257</italic> and IS<italic toggle="yes">1216</italic> Also Form Cointegrates by Copy-In and Targeted Conservative Routes
par: Christopher J. Harmer, et autres
Publié: (2020)

<italic toggle="yes">In Vivo</italic> Behavior of the Tandem Glycine Riboswitch in <italic toggle="yes">Bacillus subtilis</italic>
par: Arianne M. Babina, et autres
Publié: (2017)

Segregation but Not Replication of the <italic toggle="yes">Pseudomonas aeruginosa</italic> Chromosome Terminates at <italic toggle="yes">Dif</italic>
par: Bijit K. Bhowmik, et autres
Publié: (2018)

Live <italic toggle="yes">In Vivo</italic> Imaging of <italic toggle="yes">Plasmodium</italic> Invasion of the Mosquito Midgut
par: Nathanie Trisnadi, et autres
Publié: (2020)

Identification of Novel Host Interactors of Effectors Secreted by <italic toggle="yes">Salmonella</italic> and <italic toggle="yes">Citrobacter</italic>
par: Ryan L. Sontag, et autres
Publié: (2016)

<italic toggle="yes">luxR</italic> Homolog-Linked Biosynthetic Gene Clusters in <italic toggle="yes">Proteobacteria</italic>
par: Carolyn A. Brotherton, et autres
Publié: (2018)

Genomes of Planktonic <italic toggle="yes">Acidimicrobiales</italic>: Widening Horizons for Marine <italic toggle="yes">Actinobacteria</italic> by Metagenomics
par: Carolina Megumi Mizuno, et autres
Publié: (2015)

An Engineered Methanogenic Pathway Derived from the Domains <italic toggle="yes">Bacteria</italic> and <italic toggle="yes">Archaea</italic>
par: Daniel J. Lessner, et autres
Publié: (2010)

<italic toggle="yes">Shigella flexneri</italic> Adherence Factor Expression in <italic toggle="yes">In Vivo</italic>-Like Conditions
par: Rachael B. Chanin, et autres
Publié: (2019)

Genomic Variation among Strains of <italic toggle="yes">Crithidia bombi</italic> and <italic toggle="yes">C. expoeki</italic>
par: Evgeny Gerasimov, et autres
Publié: (2019)

Reclassification of the Taxonomic Framework of Orders <italic toggle="yes">Cellvibrionales, Oceanospirillales, Pseudomonadales</italic>, and <italic toggle="yes">Alteromonadales</italic> in Class <italic toggle="yes">Gammaproteobacteria</italic> through Phylogenomic Tree Analysis
par: Hu Liao, et autres
Publié: (2020)

The Birth and Demise of the IS<italic toggle="yes">Apl1</italic>-<italic toggle="yes">mcr-1</italic>-IS<italic toggle="yes">Apl1</italic> Composite Transposon: the Vehicle for Transferable Colistin Resistance
par: Erik Snesrud, et autres
Publié: (2018)

Modulation of Aneuploidy in <italic toggle="yes">Leishmania donovani</italic> during Adaptation to Different <italic toggle="yes">In Vitro</italic> and <italic toggle="yes">In Vivo</italic> Environments and Its Impact on Gene Expression
par: F. Dumetz, et autres
Publié: (2017)

<italic toggle="yes">Staphylococcus aureus</italic> Responds to the Central Metabolite Pyruvate To Regulate Virulence
par: Lamia Harper, et autres
Publié: (2018)

Genome-Wide Chromatin Immunoprecipitation Sequencing Analysis of the <italic toggle="yes">Penicillium chrysogenum</italic> Velvet Protein PcVelA Identifies Methyltransferase PcLlmA as a Novel Downstream Regulator of Fungal Development
par: Kordula Becker, et autres
Publié: (2016)

An <italic toggle="yes">In Vitro</italic> Chicken Gut Model Demonstrates Transfer of a Multidrug Resistance Plasmid from <italic toggle="yes">Salmonella</italic> to Commensal <italic toggle="yes">Escherichia coli</italic>
par: Roderick M. Card, et autres
Publié: (2017)

Disarming Fungal Pathogens: <italic toggle="yes">Bacillus safensis</italic> Inhibits Virulence Factor Production and Biofilm Formation by <italic toggle="yes">Cryptococcus neoformans</italic> and <italic toggle="yes">Candida albicans</italic>
par: François L. Mayer, et autres
Publié: (2017)

Immune Regulation of <italic toggle="yes">Plasmodium</italic> Is <italic toggle="yes">Anopheles</italic> Species Specific and Infection Intensity Dependent
par: Maria L. Simões, et autres
Publié: (2017)

The Gut Microbiome of the Vector <italic toggle="yes">Lutzomyia longipalpis</italic> Is Essential for Survival of <italic toggle="yes">Leishmania infantum</italic>
par: Patrick H. Kelly, et autres
Publié: (2017)

A Mobile Element in <italic toggle="yes">mutS</italic> Drives Hypermutation in a Marine <italic toggle="yes">Vibrio</italic>
par: Nathaniel D. Chu, et autres
Publié: (2017)

Adaptive Evolution of RH5 in Ape <italic toggle="yes">Plasmodium</italic> species of the <italic toggle="yes">Laverania</italic> Subgenus
par: Lindsey J. Plenderleith, et autres
Publié: (2018)

<italic toggle="yes">Anopheles</italic> Salivary Gland Architecture Shapes <italic toggle="yes">Plasmodium</italic> Sporozoite Availability for Transmission
par: Michael B. Wells, et autres
Publié: (2019)