Intrinsic determinants of Aβ(12-24) pH-dependent self-assembly revealed by combined computational and experimental studies.

The propensity of amyloid-β (Aβ) peptide to self-assemble into highly ordered amyloid structures lies at the core of their accumulation in the brain during Alzheimer's disease. By using all-atom explicit solvent replica exchange molecular dynamics simulations, we elucidated at the atomic level...

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Autores principales: Weixin Xu, Ce Zhang, Philippe Derreumaux, Astrid Gräslund, Ludmilla Morozova-Roche, Yuguang Mu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/4079a91e85d845d3bf851bbc3640a3c0
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