MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer

Summary: Activation of mitogenic signaling pathways is a common oncogenic driver of many solid tumors including lung cancer. Although activating mutations in the mitogen-activated protein kinase (MAPK) pathway are prevalent in non-small cell lung cancers, MAPK pathway activity, counterintuitively, i...

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Main Authors: Rebecca Caeser, Christopher Hulton, Emily Costa, Vidushi Durani, Megan Little, Xiaoping Chen, Sam E. Tischfield, Marina Asher, Faruk Erdem Kombak, Shweta S. Chavan, Nisargbhai S. Shah, Metamia Ciampricotti, Elisa de Stanchina, John T. Poirier, Charles M. Rudin, Triparna Sen
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Biological sciences
Cell biology
Molecular biology
Science
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Online Access:https://doaj.org/article/408084487e324b9abf64eba52e8ffc2a
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https://doaj.org/article/408084487e324b9abf64eba52e8ffc2a

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