Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.

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Main Authors:	Soojin Kim, Yvette C. Wong, Fanding Gao, Dimitri Krainc
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a
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spelling	oai:doaj.org-article:40982e38dcd44c1f9dff1e73b1f33d9a2021-12-02T11:44:50ZDysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease10.1038/s41467-021-22113-32041-1723https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22113-3https://doaj.org/toc/2041-1723Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.Soojin KimYvette C. WongFanding GaoDimitri KraincNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
description	Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here, the authors show mitochondria-lysosome contacts are prolonged and defective in heterozygous mutant GBA1 neurons, which is caused by defective modulation of TBC1D15 due to decreased GBA1 activity.
format	article
author	Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc
author_facet	Soojin Kim Yvette C. Wong Fanding Gao Dimitri Krainc
author_sort	Soojin Kim
title	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_short	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_full	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_fullStr	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_full_unstemmed	Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
title_sort	dysregulation of mitochondria-lysosome contacts by gba1 dysfunction in dopaminergic neuronal models of parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/40982e38dcd44c1f9dff1e73b1f33d9a
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Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

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