Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides

Abstract The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic excha...

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Autores principales:	Andrés M. Caraballo-Rodríguez, Pieter C. Dorrestein, Monica T. Pupo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/40ff7b9830524301bcb0c9b7f66541ad
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spelling	oai:doaj.org-article:40ff7b9830524301bcb0c9b7f66541ad2021-12-02T11:40:44ZMolecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides10.1038/s41598-017-05532-52045-2322https://doaj.org/article/40ff7b9830524301bcb0c9b7f66541ad2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05532-5https://doaj.org/toc/2045-2322Abstract The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investigate metabolic exchange in the laboratory is through microbial interactions. Here, we describe the chemical study of selected endophytes isolated from the Brazilian medicinal plant Lychnophora ericoides by pairwise inter-kingdom interactions in order to correlate the impact of co-cultivation to their metabolic profiles. Combining mass spectrometry tools and NMR analyses, a total of 29 compounds were identified. These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and leupeptins chemical families. Two of the identified compounds correspond to a new fungal metabolite (29) and a new actinobacterial angucycline-derivative (23). Our results revealed a substantial arsenal of small molecules induced by microbial interactions, as we begin to unravel the complexity of microbial interactions associated with endophytic systems.Andrés M. Caraballo-RodríguezPieter C. DorresteinMonica T. PupoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrés M. Caraballo-Rodríguez Pieter C. Dorrestein Monica T. Pupo Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
description	Abstract The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investigate metabolic exchange in the laboratory is through microbial interactions. Here, we describe the chemical study of selected endophytes isolated from the Brazilian medicinal plant Lychnophora ericoides by pairwise inter-kingdom interactions in order to correlate the impact of co-cultivation to their metabolic profiles. Combining mass spectrometry tools and NMR analyses, a total of 29 compounds were identified. These compounds are members of polyene macrocycles, pyrroloindole alkaloids, angucyclines, and leupeptins chemical families. Two of the identified compounds correspond to a new fungal metabolite (29) and a new actinobacterial angucycline-derivative (23). Our results revealed a substantial arsenal of small molecules induced by microbial interactions, as we begin to unravel the complexity of microbial interactions associated with endophytic systems.
format	article
author	Andrés M. Caraballo-Rodríguez Pieter C. Dorrestein Monica T. Pupo
author_facet	Andrés M. Caraballo-Rodríguez Pieter C. Dorrestein Monica T. Pupo
author_sort	Andrés M. Caraballo-Rodríguez
title	Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
title_short	Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
title_full	Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
title_fullStr	Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
title_full_unstemmed	Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
title_sort	molecular inter-kingdom interactions of endophytes isolated from lychnophora ericoides
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/40ff7b9830524301bcb0c9b7f66541ad
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_version_	1718395577126879232

Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides

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