Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such re...

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Autores principales:	Hua Liang, Liufu Deng, Yuzhu Hou, Xiangjiao Meng, Xiaona Huang, Enyu Rao, Wenxin Zheng, Helena Mauceri, Matthias Mack, Meng Xu, Yang-Xin Fu, Ralph R. Weichselbaum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41119c097be14bc98b46b9c80e885446
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spelling	oai:doaj.org-article:41119c097be14bc98b46b9c80e8854462021-12-02T14:43:00ZHost STING-dependent MDSC mobilization drives extrinsic radiation resistance10.1038/s41467-017-01566-52041-1723https://doaj.org/article/41119c097be14bc98b46b9c80e8854462017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01566-5https://doaj.org/toc/2041-1723Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such resistance.Hua LiangLiufu DengYuzhu HouXiangjiao MengXiaona HuangEnyu RaoWenxin ZhengHelena MauceriMatthias MackMeng XuYang-Xin FuRalph R. WeichselbaumNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hua Liang Liufu Deng Yuzhu Hou Xiangjiao Meng Xiaona Huang Enyu Rao Wenxin Zheng Helena Mauceri Matthias Mack Meng Xu Yang-Xin Fu Ralph R. Weichselbaum Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
description	Tumors often develop resistance to radiotherapy. Here the authors show that irradiation leads to a CCR2-dependent infiltration by myeloid derived suppressor cells that promote radio-resistance through inhibition of adaptive immune responses and that the use of CCR2 antibodies in mice reduces such resistance.
format	article
author	Hua Liang Liufu Deng Yuzhu Hou Xiangjiao Meng Xiaona Huang Enyu Rao Wenxin Zheng Helena Mauceri Matthias Mack Meng Xu Yang-Xin Fu Ralph R. Weichselbaum
author_facet	Hua Liang Liufu Deng Yuzhu Hou Xiangjiao Meng Xiaona Huang Enyu Rao Wenxin Zheng Helena Mauceri Matthias Mack Meng Xu Yang-Xin Fu Ralph R. Weichselbaum
author_sort	Hua Liang
title	Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
title_short	Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
title_full	Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
title_fullStr	Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
title_full_unstemmed	Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
title_sort	host sting-dependent mdsc mobilization drives extrinsic radiation resistance
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/41119c097be14bc98b46b9c80e885446
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Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

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