Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand break...

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Autores principales:	Hana Hanzlikova, Evgeniia Prokhorova, Katerina Krejcikova, Zuzana Cihlarova, Ilona Kalasova, Jan Kubovciak, Jana Sachova, Richard Hailstone, Jan Brazina, Shereen Ghosh, Sebahattin Cirak, Joseph G. Gleeson, Ivan Ahel, Keith W. Caldecott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/412587429a3944ccb397a069e9334d8c
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spelling	oai:doaj.org-article:412587429a3944ccb397a069e9334d8c2021-12-02T15:23:00ZPathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair10.1038/s41467-020-17069-92041-1723https://doaj.org/article/412587429a3944ccb397a069e9334d8c2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17069-9https://doaj.org/toc/2041-1723Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.Hana HanzlikovaEvgeniia ProkhorovaKaterina KrejcikovaZuzana CihlarovaIlona KalasovaJan KubovciakJana SachovaRichard HailstoneJan BrazinaShereen GhoshSebahattin CirakJoseph G. GleesonIvan AhelKeith W. CaldecottNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hana Hanzlikova Evgeniia Prokhorova Katerina Krejcikova Zuzana Cihlarova Ilona Kalasova Jan Kubovciak Jana Sachova Richard Hailstone Jan Brazina Shereen Ghosh Sebahattin Cirak Joseph G. Gleeson Ivan Ahel Keith W. Caldecott Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
description	Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.
format	article
author	Hana Hanzlikova Evgeniia Prokhorova Katerina Krejcikova Zuzana Cihlarova Ilona Kalasova Jan Kubovciak Jana Sachova Richard Hailstone Jan Brazina Shereen Ghosh Sebahattin Cirak Joseph G. Gleeson Ivan Ahel Keith W. Caldecott
author_facet	Hana Hanzlikova Evgeniia Prokhorova Katerina Krejcikova Zuzana Cihlarova Ilona Kalasova Jan Kubovciak Jana Sachova Richard Hailstone Jan Brazina Shereen Ghosh Sebahattin Cirak Joseph G. Gleeson Ivan Ahel Keith W. Caldecott
author_sort	Hana Hanzlikova
title	Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
title_short	Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
title_full	Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
title_fullStr	Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
title_full_unstemmed	Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
title_sort	pathogenic arh3 mutations result in adp-ribose chromatin scars during dna strand break repair
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/412587429a3944ccb397a069e9334d8c
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Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

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