Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes

The silencing efficiency of siRNA delivered by non-viral cationic vectors is limited due to endosomal/lysosomal degradation. Here, the authors develop endoplasmic reticulum-coated vesicles as a biomimetic vector for siRNA delivery and show that they improve inhibition of tumor growth in mice in vivo...

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Autores principales: Chong Qiu, Hu-Hu Han, Jing Sun, Hai-Tao Zhang, Wei Wei, Shi-He Cui, Xin Chen, Jian-Cheng Wang, Qiang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/4188bf463b5f478382ff1f4ee67ecdef
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