Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes

The silencing efficiency of siRNA delivered by non-viral cationic vectors is limited due to endosomal/lysosomal degradation. Here, the authors develop endoplasmic reticulum-coated vesicles as a biomimetic vector for siRNA delivery and show that they improve inhibition of tumor growth in mice in vivo...

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Autores principales:	Chong Qiu, Hu-Hu Han, Jing Sun, Hai-Tao Zhang, Wei Wei, Shi-He Cui, Xin Chen, Jian-Cheng Wang, Qiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4188bf463b5f478382ff1f4ee67ecdef
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spelling	oai:doaj.org-article:4188bf463b5f478382ff1f4ee67ecdef2021-12-02T17:31:21ZRegulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes10.1038/s41467-019-10562-w2041-1723https://doaj.org/article/4188bf463b5f478382ff1f4ee67ecdef2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10562-whttps://doaj.org/toc/2041-1723The silencing efficiency of siRNA delivered by non-viral cationic vectors is limited due to endosomal/lysosomal degradation. Here, the authors develop endoplasmic reticulum-coated vesicles as a biomimetic vector for siRNA delivery and show that they improve inhibition of tumor growth in mice in vivo.Chong QiuHu-Hu HanJing SunHai-Tao ZhangWei WeiShi-He CuiXin ChenJian-Cheng WangQiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chong Qiu Hu-Hu Han Jing Sun Hai-Tao Zhang Wei Wei Shi-He Cui Xin Chen Jian-Cheng Wang Qiang Zhang Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
description	The silencing efficiency of siRNA delivered by non-viral cationic vectors is limited due to endosomal/lysosomal degradation. Here, the authors develop endoplasmic reticulum-coated vesicles as a biomimetic vector for siRNA delivery and show that they improve inhibition of tumor growth in mice in vivo.
format	article
author	Chong Qiu Hu-Hu Han Jing Sun Hai-Tao Zhang Wei Wei Shi-He Cui Xin Chen Jian-Cheng Wang Qiang Zhang
author_facet	Chong Qiu Hu-Hu Han Jing Sun Hai-Tao Zhang Wei Wei Shi-He Cui Xin Chen Jian-Cheng Wang Qiang Zhang
author_sort	Chong Qiu
title	Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
title_short	Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
title_full	Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
title_fullStr	Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
title_full_unstemmed	Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
title_sort	regulating intracellular fate of sirna by endoplasmic reticulum membrane-decorated hybrid nanoplexes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/4188bf463b5f478382ff1f4ee67ecdef
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Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes

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