Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer’s transgenic mice

Abstract In preceding efforts, we demonstrated that antibiotic (ABX) cocktail-mediated perturbations of the gut microbiome in two independent transgenic lines, termed APP SWE /PS1 ΔE9 and APPPS1-21, leads to a reduction in Aβ deposition in male mice. To determine whether these observed reductions of...

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Autores principales: Hemraj B. Dodiya, Mary Frith, Ashley Sidebottom, Yajun Cao, Jason Koval, Eugene Chang, Sangram S. Sisodia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/418c266041d841b88e2c50aae0c9b6b1
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