The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

Metabolic pathways are increasingly recognized as crucial determinants of T cell function. Here the authors show that the balance between IFNγ and IL-10 production in human CD4 T cells is modulated by the cholesterol biosynthetic pathway.

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Autores principales:	Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/419107e4daf14adaaf778f8b200485e9
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spelling	oai:doaj.org-article:419107e4daf14adaaf778f8b200485e92021-12-02T16:57:19ZThe cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells10.1038/s41467-019-08332-92041-1723https://doaj.org/article/419107e4daf14adaaf778f8b200485e92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08332-9https://doaj.org/toc/2041-1723Metabolic pathways are increasingly recognized as crucial determinants of T cell function. Here the authors show that the balance between IFNγ and IL-10 production in human CD4 T cells is modulated by the cholesterol biosynthetic pathway.Esperanza PeruchaRossella MelchiottiJack A BibbyWing WuKlaus Stensgaard FrederiksenCeri A. RobertsZoe HallGaelle LeFriecKevin A. RobertsonPaul LavenderJens Gammeltoft GerwienLeonie S. TaamsJulian L. GriffinEmanuele de RinaldisLisa G. M. van BaarsenClaudia KemperPeter GhazalAndrew P. CopeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Esperanza Perucha Rossella Melchiotti Jack A Bibby Wing Wu Klaus Stensgaard Frederiksen Ceri A. Roberts Zoe Hall Gaelle LeFriec Kevin A. Robertson Paul Lavender Jens Gammeltoft Gerwien Leonie S. Taams Julian L. Griffin Emanuele de Rinaldis Lisa G. M. van Baarsen Claudia Kemper Peter Ghazal Andrew P. Cope The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
description	Metabolic pathways are increasingly recognized as crucial determinants of T cell function. Here the authors show that the balance between IFNγ and IL-10 production in human CD4 T cells is modulated by the cholesterol biosynthetic pathway.
format	article
author	Esperanza Perucha Rossella Melchiotti Jack A Bibby Wing Wu Klaus Stensgaard Frederiksen Ceri A. Roberts Zoe Hall Gaelle LeFriec Kevin A. Robertson Paul Lavender Jens Gammeltoft Gerwien Leonie S. Taams Julian L. Griffin Emanuele de Rinaldis Lisa G. M. van Baarsen Claudia Kemper Peter Ghazal Andrew P. Cope
author_facet	Esperanza Perucha Rossella Melchiotti Jack A Bibby Wing Wu Klaus Stensgaard Frederiksen Ceri A. Roberts Zoe Hall Gaelle LeFriec Kevin A. Robertson Paul Lavender Jens Gammeltoft Gerwien Leonie S. Taams Julian L. Griffin Emanuele de Rinaldis Lisa G. M. van Baarsen Claudia Kemper Peter Ghazal Andrew P. Cope
author_sort	Esperanza Perucha
title	The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
title_short	The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
title_full	The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
title_fullStr	The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
title_full_unstemmed	The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells
title_sort	cholesterol biosynthesis pathway regulates il-10 expression in human th1 cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/419107e4daf14adaaf778f8b200485e9
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The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

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