OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

OTULIN is a negative regulator of linear ubiquitination, and its deficiency in human causes multi-organ inflammations including the skin. Here the authors show, by combining various genetic tools with epidermis-specific Otulin knockout mice, that Otulin suppresses skin inflammation predominantly by...

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Bibliographic Details
Main Authors: Hannah Schünke, Ulrike Göbel, Ivan Dikic, Manolis Pasparakis
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/4192568021a0480cba718d68204be796
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