OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

OTULIN is a negative regulator of linear ubiquitination, and its deficiency in human causes multi-organ inflammations including the skin. Here the authors show, by combining various genetic tools with epidermis-specific Otulin knockout mice, that Otulin suppresses skin inflammation predominantly by...

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Autores principales:	Hannah Schünke, Ulrike Göbel, Ivan Dikic, Manolis Pasparakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4192568021a0480cba718d68204be796
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spelling	oai:doaj.org-article:4192568021a0480cba718d68204be7962021-12-02T19:16:20ZOTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice10.1038/s41467-021-25945-12041-1723https://doaj.org/article/4192568021a0480cba718d68204be7962021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25945-1https://doaj.org/toc/2041-1723OTULIN is a negative regulator of linear ubiquitination, and its deficiency in human causes multi-organ inflammations including the skin. Here the authors show, by combining various genetic tools with epidermis-specific Otulin knockout mice, that Otulin suppresses skin inflammation predominantly by inhibiting RIPK1-mediated keratinocytes necroptosis.Hannah SchünkeUlrike GöbelIvan DikicManolis PasparakisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hannah Schünke Ulrike Göbel Ivan Dikic Manolis Pasparakis OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
description	OTULIN is a negative regulator of linear ubiquitination, and its deficiency in human causes multi-organ inflammations including the skin. Here the authors show, by combining various genetic tools with epidermis-specific Otulin knockout mice, that Otulin suppresses skin inflammation predominantly by inhibiting RIPK1-mediated keratinocytes necroptosis.
format	article
author	Hannah Schünke Ulrike Göbel Ivan Dikic Manolis Pasparakis
author_facet	Hannah Schünke Ulrike Göbel Ivan Dikic Manolis Pasparakis
author_sort	Hannah Schünke
title	OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
title_short	OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
title_full	OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
title_fullStr	OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
title_full_unstemmed	OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
title_sort	otulin inhibits ripk1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4192568021a0480cba718d68204be796
work_keys_str_mv	AT hannahschunke otulininhibitsripk1mediatedkeratinocytenecroptosistopreventskininflammationinmice AT ulrikegobel otulininhibitsripk1mediatedkeratinocytenecroptosistopreventskininflammationinmice AT ivandikic otulininhibitsripk1mediatedkeratinocytenecroptosistopreventskininflammationinmice AT manolispasparakis otulininhibitsripk1mediatedkeratinocytenecroptosistopreventskininflammationinmice
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OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice

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