Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

ABSTRACT Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35...

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Auteurs principaux: Priya Luthra, Sebastian Aguirre, Benjamin C. Yen, Colette A. Pietzsch, Maria T. Sanchez-Aparicio, Bersabeh Tigabu, Lorraine K. Morlock, Adolfo García-Sastre, Daisy W. Leung, Noelle S. Williams, Ana Fernandez-Sesma, Alexander Bukreyev, Christopher F. Basler
Format: article
Langue:EN
Publié: American Society for Microbiology 2017
Sujets:
ATM signaling
DNA damage
innate immune responses
cGAS-STING pathway
Ebola virus
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/41d9ac72b3f848f2a58a74adb321bd3b
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https://doaj.org/article/41d9ac72b3f848f2a58a74adb321bd3b

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