Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres

The deposition of histone H3 variant CENP-A bound with histone H4 is a key feature designating the centromere region of a chromosome. Here the authors show acetylation on residues K5 and K12 in histone H4, mediated by the RbAp46/48-Hat1 complex, is required for deposition of CENP-A-H4 into centromer...

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Autores principales:	Wei-Hao Shang, Tetsuya Hori, Frederick G. Westhorpe, Kristina M. Godek, Atsushi Toyoda, Sadahiko Misu, Norikazu Monma, Kazuho Ikeo, Christopher W. Carroll, Yasunari Takami, Asao Fujiyama, Hiroshi Kimura, Aaron F. Straight, Tatsuo Fukagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41de434cd5f449439e320b636f2f068f
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spelling	oai:doaj.org-article:41de434cd5f449439e320b636f2f068f2021-12-02T14:39:11ZAcetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres10.1038/ncomms134652041-1723https://doaj.org/article/41de434cd5f449439e320b636f2f068f2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13465https://doaj.org/toc/2041-1723The deposition of histone H3 variant CENP-A bound with histone H4 is a key feature designating the centromere region of a chromosome. Here the authors show acetylation on residues K5 and K12 in histone H4, mediated by the RbAp46/48-Hat1 complex, is required for deposition of CENP-A-H4 into centromeres.Wei-Hao ShangTetsuya HoriFrederick G. WesthorpeKristina M. GodekAtsushi ToyodaSadahiko MisuNorikazu MonmaKazuho IkeoChristopher W. CarrollYasunari TakamiAsao FujiyamaHiroshi KimuraAaron F. StraightTatsuo FukagawaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei-Hao Shang Tetsuya Hori Frederick G. Westhorpe Kristina M. Godek Atsushi Toyoda Sadahiko Misu Norikazu Monma Kazuho Ikeo Christopher W. Carroll Yasunari Takami Asao Fujiyama Hiroshi Kimura Aaron F. Straight Tatsuo Fukagawa Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
description	The deposition of histone H3 variant CENP-A bound with histone H4 is a key feature designating the centromere region of a chromosome. Here the authors show acetylation on residues K5 and K12 in histone H4, mediated by the RbAp46/48-Hat1 complex, is required for deposition of CENP-A-H4 into centromeres.
format	article
author	Wei-Hao Shang Tetsuya Hori Frederick G. Westhorpe Kristina M. Godek Atsushi Toyoda Sadahiko Misu Norikazu Monma Kazuho Ikeo Christopher W. Carroll Yasunari Takami Asao Fujiyama Hiroshi Kimura Aaron F. Straight Tatsuo Fukagawa
author_facet	Wei-Hao Shang Tetsuya Hori Frederick G. Westhorpe Kristina M. Godek Atsushi Toyoda Sadahiko Misu Norikazu Monma Kazuho Ikeo Christopher W. Carroll Yasunari Takami Asao Fujiyama Hiroshi Kimura Aaron F. Straight Tatsuo Fukagawa
author_sort	Wei-Hao Shang
title	Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
title_short	Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
title_full	Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
title_fullStr	Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
title_full_unstemmed	Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
title_sort	acetylation of histone h4 lysine 5 and 12 is required for cenp-a deposition into centromeres
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/41de434cd5f449439e320b636f2f068f
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Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres

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