Antioxidant Properties and Cytoprotective Effect of <i>Pistacia lentiscus</i> L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death

Antioxidant Properties and Cytoprotective Effect of <i>Pistacia lentiscus</i> L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death

Aging is characterized by a progressive increase in oxidative stress, which favors lipid peroxidation and the formation of cholesterol oxide derivatives, including 7β-hydroxycholesterol (7β-OHC). This oxysterol, which is known to trigger oxidative stress, inflammation, and cell death, could contribu...

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Main Authors: Imen Ghzaiel, Amira Zarrouk, Thomas Nury, Michela Libergoli, Francesca Florio, Souha Hammouda, Franck Ménétrier, Laure Avoscan, Aline Yammine, Mohammad Samadi, Norbert Latruffe, Stefano Biressi, Débora Levy, Sérgio Paulo Bydlowski, Sonia Hammami, Anne Vejux, Mohamed Hammami, Gérard Lizard
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
aging
7β-hydroxycholesterol
mitochondria
C2C12 myoblasts
oxidative stress
peroxisome
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/41dea98b38f14b49844d725e78e7ee59
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