Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Frank Penkava, Martin Del Castillo Velasco-Herrera, Matthew D. Young, Nicole Yager, Lilian N. Nwosu, Arthur G. Pratt, Alicia Lledo Lara, Charlotte Guzzo, Ash Maroof, Lira Mamanova, Suzanne Cole, Mirjana Efremova, Davide Simone, Andrew Filer, Chrysothemis C. Brown, Andrew L. Croxford, John D. Isaacs, Sarah Teichmann, Paul Bowness, Sam Behjati, M. Hussein Al-Mossawi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41e60fd553ac455d9a90df903aa0ed85
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41e60fd553ac455d9a90df903aa0ed85
record_format	dspace
spelling	oai:doaj.org-article:41e60fd553ac455d9a90df903aa0ed852021-12-02T17:27:20ZSingle-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis10.1038/s41467-020-18513-62041-1723https://doaj.org/article/41e60fd553ac455d9a90df903aa0ed852020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18513-6https://doaj.org/toc/2041-1723Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA patients to provide a molecular immune landscape for PsA.Frank PenkavaMartin Del Castillo Velasco-HerreraMatthew D. YoungNicole YagerLilian N. NwosuArthur G. PrattAlicia Lledo LaraCharlotte GuzzoAsh MaroofLira MamanovaSuzanne ColeMirjana EfremovaDavide SimoneAndrew FilerChrysothemis C. BrownAndrew L. CroxfordJohn D. IsaacsSarah TeichmannPaul BownessSam BehjatiM. Hussein Al-MossawiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Frank Penkava Martin Del Castillo Velasco-Herrera Matthew D. Young Nicole Yager Lilian N. Nwosu Arthur G. Pratt Alicia Lledo Lara Charlotte Guzzo Ash Maroof Lira Mamanova Suzanne Cole Mirjana Efremova Davide Simone Andrew Filer Chrysothemis C. Brown Andrew L. Croxford John D. Isaacs Sarah Teichmann Paul Bowness Sam Behjati M. Hussein Al-Mossawi Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
description	Psoriatic arthritis (PsA) commonly affects patients with skin psoriasis, but its pathogenesis is still unclear. Here the authors use two types of single-cells data, mass cytometry and RNA sequencing, to describe the expansion and diversity of synovial, but not peripheral blood, CD8 T cells from PsA patients to provide a molecular immune landscape for PsA.
format	article
author	Frank Penkava Martin Del Castillo Velasco-Herrera Matthew D. Young Nicole Yager Lilian N. Nwosu Arthur G. Pratt Alicia Lledo Lara Charlotte Guzzo Ash Maroof Lira Mamanova Suzanne Cole Mirjana Efremova Davide Simone Andrew Filer Chrysothemis C. Brown Andrew L. Croxford John D. Isaacs Sarah Teichmann Paul Bowness Sam Behjati M. Hussein Al-Mossawi
author_facet	Frank Penkava Martin Del Castillo Velasco-Herrera Matthew D. Young Nicole Yager Lilian N. Nwosu Arthur G. Pratt Alicia Lledo Lara Charlotte Guzzo Ash Maroof Lira Mamanova Suzanne Cole Mirjana Efremova Davide Simone Andrew Filer Chrysothemis C. Brown Andrew L. Croxford John D. Isaacs Sarah Teichmann Paul Bowness Sam Behjati M. Hussein Al-Mossawi
author_sort	Frank Penkava
title	Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
title_short	Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
title_full	Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
title_fullStr	Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
title_full_unstemmed	Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
title_sort	single-cell sequencing reveals clonal expansions of pro-inflammatory synovial cd8 t cells expressing tissue-homing receptors in psoriatic arthritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/41e60fd553ac455d9a90df903aa0ed85
work_keys_str_mv	AT frankpenkava singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT martindelcastillovelascoherrera singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT matthewdyoung singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT nicoleyager singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT liliannnwosu singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT arthurgpratt singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT alicialledolara singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT charlotteguzzo singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT ashmaroof singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT liramamanova singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT suzannecole singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT mirjanaefremova singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT davidesimone singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT andrewfiler singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT chrysothemiscbrown singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT andrewlcroxford singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT johndisaacs singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT sarahteichmann singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT paulbowness singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT sambehjati singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis AT mhusseinalmossawi singlecellsequencingrevealsclonalexpansionsofproinflammatorysynovialcd8tcellsexpressingtissuehomingreceptorsinpsoriaticarthritis
_version_	1718380783013462016

Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis

Ejemplares similares