Consensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cells.

Consensus HIV-1 FSU-A integrase gene variants electroporated into mice induce polyfunctional antigen-specific CD4+ and CD8+ T cells.

Our objective is to create gene immunogens targeted against drug-resistant HIV-1, focusing on HIV-1 enzymes as critical components in viral replication and drug resistance. Consensus-based gene vaccines are specifically fit for variable pathogens such as HIV-1 and have many advantages over viral gen...

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Main Authors: Olga Krotova, Elizaveta Starodubova, Stefan Petkov, Linda Kostic, Julia Agapkina, David Hallengärd, Alecia Viklund, Oleg Latyshev, Eva Gelius, Tomas Dillenbeck, Vadim Karpov, Marina Gottikh, Igor M Belyakov, Vladimir Lukashov, Maria G Isaguliants
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/41f405bc9c5b461f9922170217cf23ba
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https://doaj.org/article/41f405bc9c5b461f9922170217cf23ba

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