NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

Axially chiral biaryl amino-alcohols play a pivotal role in organic synthesis and drug discovery. Here, the authors report a cooperative strategy consisting of desymmetrization followed by kinetic resolution to deliver non-classical NOBIN derivatives in high yields and enantioselectivity via NHC cat...

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Autores principales: Gongming Yang, Donghui Guo, Di Meng, Jian Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/420335355ac145a7a85467d92e8d419b
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