NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

Axially chiral biaryl amino-alcohols play a pivotal role in organic synthesis and drug discovery. Here, the authors report a cooperative strategy consisting of desymmetrization followed by kinetic resolution to deliver non-classical NOBIN derivatives in high yields and enantioselectivity via NHC cat...

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Autores principales:	Gongming Yang, Donghui Guo, Di Meng, Jian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/420335355ac145a7a85467d92e8d419b
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spelling	oai:doaj.org-article:420335355ac145a7a85467d92e8d419b2021-12-02T16:57:08ZNHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy10.1038/s41467-019-10878-72041-1723https://doaj.org/article/420335355ac145a7a85467d92e8d419b2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10878-7https://doaj.org/toc/2041-1723Axially chiral biaryl amino-alcohols play a pivotal role in organic synthesis and drug discovery. Here, the authors report a cooperative strategy consisting of desymmetrization followed by kinetic resolution to deliver non-classical NOBIN derivatives in high yields and enantioselectivity via NHC catalysis.Gongming YangDonghui GuoDi MengJian WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gongming Yang Donghui Guo Di Meng Jian Wang NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
description	Axially chiral biaryl amino-alcohols play a pivotal role in organic synthesis and drug discovery. Here, the authors report a cooperative strategy consisting of desymmetrization followed by kinetic resolution to deliver non-classical NOBIN derivatives in high yields and enantioselectivity via NHC catalysis.
format	article
author	Gongming Yang Donghui Guo Di Meng Jian Wang
author_facet	Gongming Yang Donghui Guo Di Meng Jian Wang
author_sort	Gongming Yang
title	NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
title_short	NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
title_full	NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
title_fullStr	NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
title_full_unstemmed	NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
title_sort	nhc-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/420335355ac145a7a85467d92e8d419b
work_keys_str_mv	AT gongmingyang nhccatalyzedatropoenantioselectivesynthesisofaxiallychiralbiarylaminoalcoholsviaacooperativestrategy AT donghuiguo nhccatalyzedatropoenantioselectivesynthesisofaxiallychiralbiarylaminoalcoholsviaacooperativestrategy AT dimeng nhccatalyzedatropoenantioselectivesynthesisofaxiallychiralbiarylaminoalcoholsviaacooperativestrategy AT jianwang nhccatalyzedatropoenantioselectivesynthesisofaxiallychiralbiarylaminoalcoholsviaacooperativestrategy
_version_	1718382620294774784

NHC-catalyzed atropoenantioselective synthesis of axially chiral biaryl amino alcohols via a cooperative strategy

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