Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are...

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Detalles Bibliográficos
Autores principales: Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/4231e2dcb1ae482db01a1c9297868d19
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https://doaj.org/article/4231e2dcb1ae482db01a1c9297868d19

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