DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.

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Autores principales: Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/4244008ca6074117babe9a1796cb68c8
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https://doaj.org/article/4244008ca6074117babe9a1796cb68c8

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