DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.

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Autores principales: Xiaona Sun, Ting Liu, Jun Zhao, Hansong Xia, Jun Xie, Yu Guo, Li Zhong, Mi Li, Qing Yang, Cheng Peng, Isabelle Rouvet, Alexandre Belot, Hong-Bing Shu, Pinghui Feng, Junjie Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/4244008ca6074117babe9a1796cb68c8
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spelling oai:doaj.org-article:4244008ca6074117babe9a1796cb68c82021-12-02T14:40:29ZDNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity10.1038/s41467-020-19941-02041-1723https://doaj.org/article/4244008ca6074117babe9a1796cb68c82020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19941-0https://doaj.org/toc/2041-1723The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.Xiaona SunTing LiuJun ZhaoHansong XiaJun XieYu GuoLi ZhongMi LiQing YangCheng PengIsabelle RouvetAlexandre BelotHong-Bing ShuPinghui FengJunjie ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaona Sun
Ting Liu
Jun Zhao
Hansong Xia
Jun Xie
Yu Guo
Li Zhong
Mi Li
Qing Yang
Cheng Peng
Isabelle Rouvet
Alexandre Belot
Hong-Bing Shu
Pinghui Feng
Junjie Zhang
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
description The enzyme cGAS induces innate immune responses upon recognition of cytosolic DNA. Here, using in vitro and in vivo models, the authors identify DNA-PK as a negative regulator of cGAS signalling.
format article
author Xiaona Sun
Ting Liu
Jun Zhao
Hansong Xia
Jun Xie
Yu Guo
Li Zhong
Mi Li
Qing Yang
Cheng Peng
Isabelle Rouvet
Alexandre Belot
Hong-Bing Shu
Pinghui Feng
Junjie Zhang
author_facet Xiaona Sun
Ting Liu
Jun Zhao
Hansong Xia
Jun Xie
Yu Guo
Li Zhong
Mi Li
Qing Yang
Cheng Peng
Isabelle Rouvet
Alexandre Belot
Hong-Bing Shu
Pinghui Feng
Junjie Zhang
author_sort Xiaona Sun
title DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_short DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_full DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_fullStr DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_full_unstemmed DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
title_sort dna-pk deficiency potentiates cgas-mediated antiviral innate immunity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/4244008ca6074117babe9a1796cb68c8
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