Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without causing bleeding in humanized mouse models of thrombosis...

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Autores principales:	Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42565adb3ba2424890108c840e099336
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spelling	oai:doaj.org-article:42565adb3ba2424890108c840e0993362021-12-02T14:42:13ZStructure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis10.1038/s41467-019-13928-22041-1723https://doaj.org/article/42565adb3ba2424890108c840e0993362020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13928-2https://doaj.org/toc/2041-1723Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without causing bleeding in humanized mouse models of thrombosisBrian D. AdairJosé L. AlonsoJohannes van AgthovenVincent HayesHyun Sook AhnI-Shing YuShu-Wha LinJian-Ping XiongMortimer PonczM. Amin ArnaoutNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian D. Adair José L. Alonso Johannes van Agthoven Vincent Hayes Hyun Sook Ahn I-Shing Yu Shu-Wha Lin Jian-Ping Xiong Mortimer Poncz M. Amin Arnaout Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
description	Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without causing bleeding in humanized mouse models of thrombosis
format	article
author	Brian D. Adair José L. Alonso Johannes van Agthoven Vincent Hayes Hyun Sook Ahn I-Shing Yu Shu-Wha Lin Jian-Ping Xiong Mortimer Poncz M. Amin Arnaout
author_facet	Brian D. Adair José L. Alonso Johannes van Agthoven Vincent Hayes Hyun Sook Ahn I-Shing Yu Shu-Wha Lin Jian-Ping Xiong Mortimer Poncz M. Amin Arnaout
author_sort	Brian D. Adair
title	Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
title_short	Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
title_full	Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
title_fullStr	Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
title_full_unstemmed	Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis
title_sort	structure-guided design of pure orthosteric inhibitors of αiibβ3 that prevent thrombosis but preserve hemostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/42565adb3ba2424890108c840e099336
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Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

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