Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects

Abstract Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is under debate, the protein is considered essential for renal Mg2+ reabsorption. Here, we used a Cnnm2 knock out mouse model, generated...

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Autores principales: Gijs A. C. Franken, Murat Seker, Caro Bos, Laura A. H. Siemons, Bram C. J. van der Eerden, Annabel Christ, Joost G. J. Hoenderop, René J. M. Bindels, Dominik Müller, Tilman Breiderhoff, Jeroen H. F. de Baaij
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/425e0fafae4846bc82edea83d0b50985
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https://doaj.org/article/425e0fafae4846bc82edea83d0b50985

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