Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant

Concurrent mutations in RNA-dependent RNA polymerase and spike protein emerged as the epidemiologically most successful SARS-CoV-2 variant

Abstract The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we confirmed that the aspartate replacement by glycine in position 614 is markedly more infectious. Molecular modelling suggests that the G6...

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Bibliographic Details
Main Authors: Sten Ilmjärv, Fabien Abdul, Silvia Acosta-Gutiérrez, Carolina Estarellas, Ioannis Galdadas, Marina Casimir, Marco Alessandrini, Francesco Luigi Gervasio, Karl-Heinz Krause
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/425fb19c933a4ad18acbebcbf3e961d0
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