Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection

Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8 + neurons contribute to regulating both innate and adaptive immune responses again...

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Main Authors: Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, Guillaume Hoeffel, Rafaëlle Rossignol, Clara Daher, Guilhaume Debroas, Sandrine Henri, Claerwen M. Jones, Bernard Malissen, Laura K. Mackay, Aziz Moqrich, Francis R. Carbone, Sophie Ugolini
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/42a3ec0604df491d8f51a1b9be9121c7
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Summary:Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8 + neurons contribute to regulating both innate and adaptive immune responses against HSV-1, thereby offering a potential target for therapy.

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