Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits <italic toggle="yes">Ex Vivo</italic> Lipopolysaccharide-Induced Inflammatory Responses

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits <italic toggle="yes">Ex Vivo</italic> Lipopolysaccharide-Induced Inflammatory Responses

ABSTRACT Histone deacetylase inhibitors (HDACi) modulate the transcriptional activity of all cells, including innate and adaptive immune cells. Therefore, we aimed to evaluate immunological effects of treatment with the HDACi panobinostat in HIV-infected patients during a clinical phase IIa latency...

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Main Authors: Christel Rothe Brinkmann, Jesper Falkesgaard Højen, Thomas Aagaard Rasmussen, Anne Sofie Kjær, Rikke Olesen, Paul W. Denton, Lars Østergaard, Zhengyu Ouyang, Mathias Lichterfeld, Xu Yu, Ole Schmeltz Søgaard, Charles Dinarello, Martin Tolstrup
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
T-cell immunity
clinical trials
gene expression
histone deacetylase inhibitors
human immunodeficiency virus
inflammation
Microbiology
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Online Access:https://doaj.org/article/42a41f93e9564a62ab717ed0df2a75eb
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https://doaj.org/article/42a41f93e9564a62ab717ed0df2a75eb

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