Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.

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Detalles Bibliográficos
Autores principales: Guy Biber, Aviad Ben-Shmuel, Elad Noy, Noah Joseph, Abhishek Puthenveetil, Neria Reiss, Omer Levy, Itay Lazar, Ariel Feiglin, Yanay Ofran, Meirav Kedmi, Abraham Avigdor, Sophia Fried, Mira Barda-Saad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/42c120d99789446b99e08ed0d9914e76
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