Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.

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Autores principales:	Guy Biber, Aviad Ben-Shmuel, Elad Noy, Noah Joseph, Abhishek Puthenveetil, Neria Reiss, Omer Levy, Itay Lazar, Ariel Feiglin, Yanay Ofran, Meirav Kedmi, Abraham Avigdor, Sophia Fried, Mira Barda-Saad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42c120d99789446b99e08ed0d9914e76
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spelling	oai:doaj.org-article:42c120d99789446b99e08ed0d9914e762021-12-02T18:48:11ZTargeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies10.1038/s41467-021-25842-72041-1723https://doaj.org/article/42c120d99789446b99e08ed0d9914e762021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25842-7https://doaj.org/toc/2041-1723Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.Guy BiberAviad Ben-ShmuelElad NoyNoah JosephAbhishek PuthenveetilNeria ReissOmer LevyItay LazarAriel FeiglinYanay OfranMeirav KedmiAbraham AvigdorSophia FriedMira Barda-SaadNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guy Biber Aviad Ben-Shmuel Elad Noy Noah Joseph Abhishek Puthenveetil Neria Reiss Omer Levy Itay Lazar Ariel Feiglin Yanay Ofran Meirav Kedmi Abraham Avigdor Sophia Fried Mira Barda-Saad Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
description	Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating its therapeutic potential in vitro and in vivo.
format	article
author	Guy Biber Aviad Ben-Shmuel Elad Noy Noah Joseph Abhishek Puthenveetil Neria Reiss Omer Levy Itay Lazar Ariel Feiglin Yanay Ofran Meirav Kedmi Abraham Avigdor Sophia Fried Mira Barda-Saad
author_facet	Guy Biber Aviad Ben-Shmuel Elad Noy Noah Joseph Abhishek Puthenveetil Neria Reiss Omer Levy Itay Lazar Ariel Feiglin Yanay Ofran Meirav Kedmi Abraham Avigdor Sophia Fried Mira Barda-Saad
author_sort	Guy Biber
title	Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
title_short	Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
title_full	Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
title_fullStr	Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
title_full_unstemmed	Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies
title_sort	targeting the actin nucleation promoting factor wasp provides a therapeutic approach for hematopoietic malignancies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/42c120d99789446b99e08ed0d9914e76
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Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies

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