Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

Abstract Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated c...

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Autores principales: Helvira Melo, Lilian Basso, Mircea Iftinca, Wallace K. MacNaughton, Morley D. Hollenberg, Derek M. McKay, Christophe Altier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/42ced415c4b94ea690383c643cde70f5
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