H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines

H3.3K27M Mutation Controls Cell Growth and Resistance to Therapies in Pediatric Glioma Cell Lines

High-grade gliomas represent the most lethal class of pediatric tumors, and their resistance to both radio- and chemotherapy is associated with a poor prognosis. Recurrent mutations affecting histone genes drive the tumorigenesis of some pediatric high-grade gliomas, and H3K27M mutations are notably...

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Auteurs principaux: Andria Rakotomalala, Quentin Bailleul, Clara Savary, Mélanie Arcicasa, Maud Hamadou, Paul Huchedé, Audrey Hochart, Audrey Restouin, Remy Castellano, Yves Collette, Emma Dieny, Audrey Vincent, Pierre-Olivier Angrand, Xuefen Le Bourhis, Pierre Leblond, Alessandro Furlan, Marie Castets, Eddy Pasquier, Samuel Meignan
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
H3.3K27M
glioma
child
resistance to therapies
radiotherapy
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Accès en ligne:https://doaj.org/article/42cf81e91f7b4d65b7024047c01962a6
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https://doaj.org/article/42cf81e91f7b4d65b7024047c01962a6

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