Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.

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Autores principales:	Longqi Liu, Chuanyu Liu, Andrés Quintero, Liang Wu, Yue Yuan, Mingyue Wang, Mengnan Cheng, Lizhi Leng, Liqin Xu, Guoyi Dong, Rui Li, Yang Liu, Xiaoyu Wei, Jiangshan Xu, Xiaowei Chen, Haorong Lu, Dongsheng Chen, Quanlei Wang, Qing Zhou, Xinxin Lin, Guibo Li, Shiping Liu, Qi Wang, Hongru Wang, J. Lynn Fink, Zhengliang Gao, Xin Liu, Yong Hou, Shida Zhu, Huanming Yang, Yunming Ye, Ge Lin, Fang Chen, Carl Herrmann, Roland Eils, Zhouchun Shang, Xun Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/42d28702523949a9a66ecb6233ecbdda
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:42d28702523949a9a66ecb6233ecbdda2021-12-02T16:57:07ZDeconvolution of single-cell multi-omics layers reveals regulatory heterogeneity10.1038/s41467-018-08205-72041-1723https://doaj.org/article/42d28702523949a9a66ecb6233ecbdda2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08205-7https://doaj.org/toc/2041-1723Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.Longqi LiuChuanyu LiuAndrés QuinteroLiang WuYue YuanMingyue WangMengnan ChengLizhi LengLiqin XuGuoyi DongRui LiYang LiuXiaoyu WeiJiangshan XuXiaowei ChenHaorong LuDongsheng ChenQuanlei WangQing ZhouXinxin LinGuibo LiShiping LiuQi WangHongru WangJ. Lynn FinkZhengliang GaoXin LiuYong HouShida ZhuHuanming YangYunming YeGe LinFang ChenCarl HerrmannRoland EilsZhouchun ShangXun XuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Longqi Liu Chuanyu Liu Andrés Quintero Liang Wu Yue Yuan Mingyue Wang Mengnan Cheng Lizhi Leng Liqin Xu Guoyi Dong Rui Li Yang Liu Xiaoyu Wei Jiangshan Xu Xiaowei Chen Haorong Lu Dongsheng Chen Quanlei Wang Qing Zhou Xinxin Lin Guibo Li Shiping Liu Qi Wang Hongru Wang J. Lynn Fink Zhengliang Gao Xin Liu Yong Hou Shida Zhu Huanming Yang Yunming Ye Ge Lin Fang Chen Carl Herrmann Roland Eils Zhouchun Shang Xun Xu Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
description	Heterogeneity in gene expression and epigenetic states exists across individual cells. Here, the authors develop scCAT-seq, a technique for simultaneously performing ATAC-seq and RNA-seq within the same single cell.
format	article
author	Longqi Liu Chuanyu Liu Andrés Quintero Liang Wu Yue Yuan Mingyue Wang Mengnan Cheng Lizhi Leng Liqin Xu Guoyi Dong Rui Li Yang Liu Xiaoyu Wei Jiangshan Xu Xiaowei Chen Haorong Lu Dongsheng Chen Quanlei Wang Qing Zhou Xinxin Lin Guibo Li Shiping Liu Qi Wang Hongru Wang J. Lynn Fink Zhengliang Gao Xin Liu Yong Hou Shida Zhu Huanming Yang Yunming Ye Ge Lin Fang Chen Carl Herrmann Roland Eils Zhouchun Shang Xun Xu
author_facet	Longqi Liu Chuanyu Liu Andrés Quintero Liang Wu Yue Yuan Mingyue Wang Mengnan Cheng Lizhi Leng Liqin Xu Guoyi Dong Rui Li Yang Liu Xiaoyu Wei Jiangshan Xu Xiaowei Chen Haorong Lu Dongsheng Chen Quanlei Wang Qing Zhou Xinxin Lin Guibo Li Shiping Liu Qi Wang Hongru Wang J. Lynn Fink Zhengliang Gao Xin Liu Yong Hou Shida Zhu Huanming Yang Yunming Ye Ge Lin Fang Chen Carl Herrmann Roland Eils Zhouchun Shang Xun Xu
author_sort	Longqi Liu
title	Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
title_short	Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
title_full	Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
title_fullStr	Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
title_full_unstemmed	Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
title_sort	deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/42d28702523949a9a66ecb6233ecbdda
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_version_	1718382621105324032

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

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