A meta-analysis of genome-wide association studies identifies multiple longevity genes

Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival percentile, the authors report two additional loci locat...

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Autores principales:	Joris Deelen, Daniel S. Evans, Dan E. Arking, Niccolò Tesi, Marianne Nygaard, Xiaomin Liu, Mary K. Wojczynski, Mary L. Biggs, Ashley van der Spek, Gil Atzmon, Erin B. Ware, Chloé Sarnowski, Albert V. Smith, Ilkka Seppälä, Heather J. Cordell, Janina Dose, Najaf Amin, Alice M. Arnold, Kristin L. Ayers, Nir Barzilai, Elizabeth J. Becker, Marian Beekman, Hélène Blanché, Kaare Christensen, Lene Christiansen, Joanna C. Collerton, Sarah Cubaynes, Steven R. Cummings, Karen Davies, Birgit Debrabant, Jean-François Deleuze, Rachel Duncan, Jessica D. Faul, Claudio Franceschi, Pilar Galan, Vilmundur Gudnason, Tamara B. Harris, Martijn Huisman, Mikko A. Hurme, Carol Jagger, Iris Jansen, Marja Jylhä, Mika Kähönen, David Karasik, Sharon L. R. Kardia, Andrew Kingston, Thomas B. L. Kirkwood, Lenore J. Launer, Terho Lehtimäki, Wolfgang Lieb, Leo-Pekka Lyytikäinen, Carmen Martin-Ruiz, Junxia Min, Almut Nebel, Anne B. Newman, Chao Nie, Ellen A. Nohr, Eric S. Orwoll, Thomas T. Perls, Michael A. Province, Bruce M. Psaty, Olli T. Raitakari, Marcel J. T. Reinders, Jean-Marie Robine, Jerome I. Rotter, Paola Sebastiani, Jennifer Smith, Thorkild I. A. Sørensen, Kent D. Taylor, André G. Uitterlinden, Wiesje van der Flier, Sven J. van der Lee, Cornelia M. van Duijn, Diana van Heemst, James W. Vaupel, David Weir, Kenny Ye, Yi Zeng, Wanlin Zheng, Henne Holstege, Douglas P. Kiel, Kathryn L. Lunetta, P. Eline Slagboom, Joanne M. Murabito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43040ac329044c8a980e87b5849d94cd
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spelling	oai:doaj.org-article:43040ac329044c8a980e87b5849d94cd2021-12-02T17:33:22ZA meta-analysis of genome-wide association studies identifies multiple longevity genes10.1038/s41467-019-11558-22041-1723https://doaj.org/article/43040ac329044c8a980e87b5849d94cd2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11558-2https://doaj.org/toc/2041-1723Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival percentile, the authors report two additional loci located in the APOE locus and near GPR78.Joris DeelenDaniel S. EvansDan E. ArkingNiccolò TesiMarianne NygaardXiaomin LiuMary K. WojczynskiMary L. BiggsAshley van der SpekGil AtzmonErin B. WareChloé SarnowskiAlbert V. SmithIlkka SeppäläHeather J. CordellJanina DoseNajaf AminAlice M. ArnoldKristin L. AyersNir BarzilaiElizabeth J. BeckerMarian BeekmanHélène BlanchéKaare ChristensenLene ChristiansenJoanna C. CollertonSarah CubaynesSteven R. CummingsKaren DaviesBirgit DebrabantJean-François DeleuzeRachel DuncanJessica D. FaulClaudio FranceschiPilar GalanVilmundur GudnasonTamara B. HarrisMartijn HuismanMikko A. HurmeCarol JaggerIris JansenMarja JylhäMika KähönenDavid KarasikSharon L. R. KardiaAndrew KingstonThomas B. L. KirkwoodLenore J. LaunerTerho LehtimäkiWolfgang LiebLeo-Pekka LyytikäinenCarmen Martin-RuizJunxia MinAlmut NebelAnne B. NewmanChao NieEllen A. NohrEric S. OrwollThomas T. PerlsMichael A. ProvinceBruce M. PsatyOlli T. RaitakariMarcel J. T. ReindersJean-Marie RobineJerome I. RotterPaola SebastianiJennifer SmithThorkild I. A. SørensenKent D. TaylorAndré G. UitterlindenWiesje van der FlierSven J. van der LeeCornelia M. van DuijnDiana van HeemstJames W. VaupelDavid WeirKenny YeYi ZengWanlin ZhengHenne HolstegeDouglas P. KielKathryn L. LunettaP. Eline SlagboomJoanne M. MurabitoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joris Deelen Daniel S. Evans Dan E. Arking Niccolò Tesi Marianne Nygaard Xiaomin Liu Mary K. Wojczynski Mary L. Biggs Ashley van der Spek Gil Atzmon Erin B. Ware Chloé Sarnowski Albert V. Smith Ilkka Seppälä Heather J. Cordell Janina Dose Najaf Amin Alice M. Arnold Kristin L. Ayers Nir Barzilai Elizabeth J. Becker Marian Beekman Hélène Blanché Kaare Christensen Lene Christiansen Joanna C. Collerton Sarah Cubaynes Steven R. Cummings Karen Davies Birgit Debrabant Jean-François Deleuze Rachel Duncan Jessica D. Faul Claudio Franceschi Pilar Galan Vilmundur Gudnason Tamara B. Harris Martijn Huisman Mikko A. Hurme Carol Jagger Iris Jansen Marja Jylhä Mika Kähönen David Karasik Sharon L. R. Kardia Andrew Kingston Thomas B. L. Kirkwood Lenore J. Launer Terho Lehtimäki Wolfgang Lieb Leo-Pekka Lyytikäinen Carmen Martin-Ruiz Junxia Min Almut Nebel Anne B. Newman Chao Nie Ellen A. Nohr Eric S. Orwoll Thomas T. Perls Michael A. Province Bruce M. Psaty Olli T. Raitakari Marcel J. T. Reinders Jean-Marie Robine Jerome I. Rotter Paola Sebastiani Jennifer Smith Thorkild I. A. Sørensen Kent D. Taylor André G. Uitterlinden Wiesje van der Flier Sven J. van der Lee Cornelia M. van Duijn Diana van Heemst James W. Vaupel David Weir Kenny Ye Yi Zeng Wanlin Zheng Henne Holstege Douglas P. Kiel Kathryn L. Lunetta P. Eline Slagboom Joanne M. Murabito A meta-analysis of genome-wide association studies identifies multiple longevity genes
description	Genome-wide association studies have only revealed a handful of genetic loci for longevity. Here, in a case–control design based on phenotype definitions of individuals surviving at or beyond the age corresponding to the 90th and 99th survival percentile, the authors report two additional loci located in the APOE locus and near GPR78.
format	article
author	Joris Deelen Daniel S. Evans Dan E. Arking Niccolò Tesi Marianne Nygaard Xiaomin Liu Mary K. Wojczynski Mary L. Biggs Ashley van der Spek Gil Atzmon Erin B. Ware Chloé Sarnowski Albert V. Smith Ilkka Seppälä Heather J. Cordell Janina Dose Najaf Amin Alice M. Arnold Kristin L. Ayers Nir Barzilai Elizabeth J. Becker Marian Beekman Hélène Blanché Kaare Christensen Lene Christiansen Joanna C. Collerton Sarah Cubaynes Steven R. Cummings Karen Davies Birgit Debrabant Jean-François Deleuze Rachel Duncan Jessica D. Faul Claudio Franceschi Pilar Galan Vilmundur Gudnason Tamara B. Harris Martijn Huisman Mikko A. Hurme Carol Jagger Iris Jansen Marja Jylhä Mika Kähönen David Karasik Sharon L. R. Kardia Andrew Kingston Thomas B. L. Kirkwood Lenore J. Launer Terho Lehtimäki Wolfgang Lieb Leo-Pekka Lyytikäinen Carmen Martin-Ruiz Junxia Min Almut Nebel Anne B. Newman Chao Nie Ellen A. Nohr Eric S. Orwoll Thomas T. Perls Michael A. Province Bruce M. Psaty Olli T. Raitakari Marcel J. T. Reinders Jean-Marie Robine Jerome I. Rotter Paola Sebastiani Jennifer Smith Thorkild I. A. Sørensen Kent D. Taylor André G. Uitterlinden Wiesje van der Flier Sven J. van der Lee Cornelia M. van Duijn Diana van Heemst James W. Vaupel David Weir Kenny Ye Yi Zeng Wanlin Zheng Henne Holstege Douglas P. Kiel Kathryn L. Lunetta P. Eline Slagboom Joanne M. Murabito
author_facet	Joris Deelen Daniel S. Evans Dan E. Arking Niccolò Tesi Marianne Nygaard Xiaomin Liu Mary K. Wojczynski Mary L. Biggs Ashley van der Spek Gil Atzmon Erin B. Ware Chloé Sarnowski Albert V. Smith Ilkka Seppälä Heather J. Cordell Janina Dose Najaf Amin Alice M. Arnold Kristin L. Ayers Nir Barzilai Elizabeth J. Becker Marian Beekman Hélène Blanché Kaare Christensen Lene Christiansen Joanna C. Collerton Sarah Cubaynes Steven R. Cummings Karen Davies Birgit Debrabant Jean-François Deleuze Rachel Duncan Jessica D. Faul Claudio Franceschi Pilar Galan Vilmundur Gudnason Tamara B. Harris Martijn Huisman Mikko A. Hurme Carol Jagger Iris Jansen Marja Jylhä Mika Kähönen David Karasik Sharon L. R. Kardia Andrew Kingston Thomas B. L. Kirkwood Lenore J. Launer Terho Lehtimäki Wolfgang Lieb Leo-Pekka Lyytikäinen Carmen Martin-Ruiz Junxia Min Almut Nebel Anne B. Newman Chao Nie Ellen A. Nohr Eric S. Orwoll Thomas T. Perls Michael A. Province Bruce M. Psaty Olli T. Raitakari Marcel J. T. Reinders Jean-Marie Robine Jerome I. Rotter Paola Sebastiani Jennifer Smith Thorkild I. A. Sørensen Kent D. Taylor André G. Uitterlinden Wiesje van der Flier Sven J. van der Lee Cornelia M. van Duijn Diana van Heemst James W. Vaupel David Weir Kenny Ye Yi Zeng Wanlin Zheng Henne Holstege Douglas P. Kiel Kathryn L. Lunetta P. Eline Slagboom Joanne M. Murabito
author_sort	Joris Deelen
title	A meta-analysis of genome-wide association studies identifies multiple longevity genes
title_short	A meta-analysis of genome-wide association studies identifies multiple longevity genes
title_full	A meta-analysis of genome-wide association studies identifies multiple longevity genes
title_fullStr	A meta-analysis of genome-wide association studies identifies multiple longevity genes
title_full_unstemmed	A meta-analysis of genome-wide association studies identifies multiple longevity genes
title_sort	meta-analysis of genome-wide association studies identifies multiple longevity genes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/43040ac329044c8a980e87b5849d94cd
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A meta-analysis of genome-wide association studies identifies multiple longevity genes

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