Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

Mechanical strength of in situ assembled nuclear lamin filaments arranged in a 3D meshwork is unclear. Here, using mechanical, structural and simulation tools, the authors report the hierarchical organization of the lamin meshwork that imparts strength and toughness to lamin filaments at par with si...

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Bibliographic Details
Main Authors: K. Tanuj Sapra, Zhao Qin, Anna Dubrovsky-Gaupp, Ueli Aebi, Daniel J. Müller, Markus J. Buehler, Ohad Medalia
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
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Online Access:https://doaj.org/article/430a388404c140a1a17718154858bcf0
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