Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

Mechanical strength of in situ assembled nuclear lamin filaments arranged in a 3D meshwork is unclear. Here, using mechanical, structural and simulation tools, the authors report the hierarchical organization of the lamin meshwork that imparts strength and toughness to lamin filaments at par with si...

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Autores principales:	K. Tanuj Sapra, Zhao Qin, Anna Dubrovsky-Gaupp, Ueli Aebi, Daniel J. Müller, Markus J. Buehler, Ohad Medalia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/430a388404c140a1a17718154858bcf0
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spelling	oai:doaj.org-article:430a388404c140a1a17718154858bcf02021-12-02T15:33:31ZNonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina10.1038/s41467-020-20049-82041-1723https://doaj.org/article/430a388404c140a1a17718154858bcf02020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20049-8https://doaj.org/toc/2041-1723Mechanical strength of in situ assembled nuclear lamin filaments arranged in a 3D meshwork is unclear. Here, using mechanical, structural and simulation tools, the authors report the hierarchical organization of the lamin meshwork that imparts strength and toughness to lamin filaments at par with silk and Kevlar®K. Tanuj SapraZhao QinAnna Dubrovsky-GauppUeli AebiDaniel J. MüllerMarkus J. BuehlerOhad MedaliaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. Tanuj Sapra Zhao Qin Anna Dubrovsky-Gaupp Ueli Aebi Daniel J. Müller Markus J. Buehler Ohad Medalia Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
description	Mechanical strength of in situ assembled nuclear lamin filaments arranged in a 3D meshwork is unclear. Here, using mechanical, structural and simulation tools, the authors report the hierarchical organization of the lamin meshwork that imparts strength and toughness to lamin filaments at par with silk and Kevlar®
format	article
author	K. Tanuj Sapra Zhao Qin Anna Dubrovsky-Gaupp Ueli Aebi Daniel J. Müller Markus J. Buehler Ohad Medalia
author_facet	K. Tanuj Sapra Zhao Qin Anna Dubrovsky-Gaupp Ueli Aebi Daniel J. Müller Markus J. Buehler Ohad Medalia
author_sort	K. Tanuj Sapra
title	Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
title_short	Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
title_full	Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
title_fullStr	Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
title_full_unstemmed	Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
title_sort	nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/430a388404c140a1a17718154858bcf0
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Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

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