Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

Mechanical strength of in situ assembled nuclear lamin filaments arranged in a 3D meshwork is unclear. Here, using mechanical, structural and simulation tools, the authors report the hierarchical organization of the lamin meshwork that imparts strength and toughness to lamin filaments at par with si...

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Autores principales: K. Tanuj Sapra, Zhao Qin, Anna Dubrovsky-Gaupp, Ueli Aebi, Daniel J. Müller, Markus J. Buehler, Ohad Medalia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/430a388404c140a1a17718154858bcf0
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