Short-chain ketone production by engineered polyketide synthases in Streptomyces albus

Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrolysates in Streptomyces, which can increase the oct...

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Autores principales:	Satoshi Yuzawa, Mona Mirsiaghi, Renee Jocic, Tatsuya Fujii, Fabrice Masson, Veronica T. Benites, Edward E. K. Baidoo, Eric Sundstrom, Deepti Tanjore, Todd R. Pray, Anthe George, Ryan W. Davis, John M. Gladden, Blake A. Simmons, Leonard Katz, Jay D. Keasling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/43191a49361742d58a6a635e4ab9761b
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spelling	oai:doaj.org-article:43191a49361742d58a6a635e4ab9761b2021-12-02T16:56:58ZShort-chain ketone production by engineered polyketide synthases in Streptomyces albus10.1038/s41467-018-07040-02041-1723https://doaj.org/article/43191a49361742d58a6a635e4ab9761b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07040-0https://doaj.org/toc/2041-1723Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrolysates in Streptomyces, which can increase the octane of gasoline.Satoshi YuzawaMona MirsiaghiRenee JocicTatsuya FujiiFabrice MassonVeronica T. BenitesEdward E. K. BaidooEric SundstromDeepti TanjoreTodd R. PrayAnthe GeorgeRyan W. DavisJohn M. GladdenBlake A. SimmonsLeonard KatzJay D. KeaslingNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoshi Yuzawa Mona Mirsiaghi Renee Jocic Tatsuya Fujii Fabrice Masson Veronica T. Benites Edward E. K. Baidoo Eric Sundstrom Deepti Tanjore Todd R. Pray Anthe George Ryan W. Davis John M. Gladden Blake A. Simmons Leonard Katz Jay D. Keasling Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
description	Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrolysates in Streptomyces, which can increase the octane of gasoline.
format	article
author	Satoshi Yuzawa Mona Mirsiaghi Renee Jocic Tatsuya Fujii Fabrice Masson Veronica T. Benites Edward E. K. Baidoo Eric Sundstrom Deepti Tanjore Todd R. Pray Anthe George Ryan W. Davis John M. Gladden Blake A. Simmons Leonard Katz Jay D. Keasling
author_facet	Satoshi Yuzawa Mona Mirsiaghi Renee Jocic Tatsuya Fujii Fabrice Masson Veronica T. Benites Edward E. K. Baidoo Eric Sundstrom Deepti Tanjore Todd R. Pray Anthe George Ryan W. Davis John M. Gladden Blake A. Simmons Leonard Katz Jay D. Keasling
author_sort	Satoshi Yuzawa
title	Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
title_short	Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
title_full	Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
title_fullStr	Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
title_full_unstemmed	Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
title_sort	short-chain ketone production by engineered polyketide synthases in streptomyces albus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/43191a49361742d58a6a635e4ab9761b
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Short-chain ketone production by engineered polyketide synthases in Streptomyces albus

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