Short-chain ketone production by engineered polyketide synthases in Streptomyces albus
Mutating natural enzymes is effective in broadening the substrate or product range, but generally leads to reduced titers. Here the authors engineer hybrid polyketide synthases for efficient production of short-chain ketones from plant biomass hydrolysates in Streptomyces, which can increase the oct...
Guardado en:
Autores principales: | Satoshi Yuzawa, Mona Mirsiaghi, Renee Jocic, Tatsuya Fujii, Fabrice Masson, Veronica T. Benites, Edward E. K. Baidoo, Eric Sundstrom, Deepti Tanjore, Todd R. Pray, Anthe George, Ryan W. Davis, John M. Gladden, Blake A. Simmons, Leonard Katz, Jay D. Keasling |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/43191a49361742d58a6a635e4ab9761b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Genomics of sponge-associated Streptomyces spp. closely related to Streptomyces albus J1074: insights into marine adaptation and secondary metabolite biosynthesis potential.
por: Elena Ian, et al.
Publicado: (2014) -
Diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Streptomyces strains
por: Hisayuki Komaki, et al.
Publicado: (2018) -
Reconstitution of a mini‐gene cluster combined with ribosome engineering led to effective enhancement of salinomycin production in Streptomyces albus
por: Dong Li, et al.
Publicado: (2021) -
Novel Type III Polyketide Synthases Biosynthesize Methylated Polyketides in Mycobacterium marinum
por: Amreesh Parvez, et al.
Publicado: (2018) -
The paradigm of the depth distribution of Loxechinus albus (Molina) in Chile
por: MORENO,CARLOS A, et al.
Publicado: (2013)