Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection

Abstract Genetically attenuated sporozoite vaccines can elicit long-lasting protection against malaria but pose risks of breakthrough infection. Chemoprophylaxis vaccination (CVac) has proven to be the most effective vaccine strategy against malaria. Here, we demonstrate that a liver stage-specific...

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Bibliographic Details
Main Authors: Tejram Sahu, Ella J. Gehrke, Yevel Flores-Garcia, Godfree Mlambo, Julia D. Romano, Isabelle Coppens
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Online Access:https://doaj.org/article/432db3d909be41fbba6bddb8eb40f52c
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