Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia

Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia

Abstract T cell prolymphocytic leukemia (T-PLL) is a rare disease with aggressive clinical course. Cytogenetic analysis, whole-exome and whole-genome sequencing have identified primary structural alterations in T-PLL, including inversion, translocation and copy number variation. Recurrent somatic mu...

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Main Authors: Shulan Tian, Henan Zhang, Pan Zhang, Michael Kalmbach, Jeong-Heon Lee, Tamas Ordog, Paul J. Hampel, Timothy G. Call, Thomas E. Witzig, Neil E. Kay, Eric W. Klee, Susan L. Slager, Huihuang Yan, Wei Ding
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/43304e766b734189afed60f90539ff6d
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https://doaj.org/article/43304e766b734189afed60f90539ff6d

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