De novo design of a reversible phosphorylation-dependent switch for membrane targeting

The ability to dynamically control protein-protein interactions and localization of proteins is critical in synthetic biological systems. Here the authors develop a peptide-based molecular switch that regulates dimer formation and lipid membrane targeting via reversible phosphorylation.

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Autores principales: Leon Harrington, Jordan M. Fletcher, Tamara Heermann, Derek N. Woolfson, Petra Schwille
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/4376b19d20ae4edab075ab555f27de80
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