De novo design of a reversible phosphorylation-dependent switch for membrane targeting

The ability to dynamically control protein-protein interactions and localization of proteins is critical in synthetic biological systems. Here the authors develop a peptide-based molecular switch that regulates dimer formation and lipid membrane targeting via reversible phosphorylation.

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Autores principales:	Leon Harrington, Jordan M. Fletcher, Tamara Heermann, Derek N. Woolfson, Petra Schwille
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4376b19d20ae4edab075ab555f27de80
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spelling	oai:doaj.org-article:4376b19d20ae4edab075ab555f27de802021-12-02T13:35:00ZDe novo design of a reversible phosphorylation-dependent switch for membrane targeting10.1038/s41467-021-21622-52041-1723https://doaj.org/article/4376b19d20ae4edab075ab555f27de802021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21622-5https://doaj.org/toc/2041-1723The ability to dynamically control protein-protein interactions and localization of proteins is critical in synthetic biological systems. Here the authors develop a peptide-based molecular switch that regulates dimer formation and lipid membrane targeting via reversible phosphorylation.Leon HarringtonJordan M. FletcherTamara HeermannDerek N. WoolfsonPetra SchwilleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leon Harrington Jordan M. Fletcher Tamara Heermann Derek N. Woolfson Petra Schwille De novo design of a reversible phosphorylation-dependent switch for membrane targeting
description	The ability to dynamically control protein-protein interactions and localization of proteins is critical in synthetic biological systems. Here the authors develop a peptide-based molecular switch that regulates dimer formation and lipid membrane targeting via reversible phosphorylation.
format	article
author	Leon Harrington Jordan M. Fletcher Tamara Heermann Derek N. Woolfson Petra Schwille
author_facet	Leon Harrington Jordan M. Fletcher Tamara Heermann Derek N. Woolfson Petra Schwille
author_sort	Leon Harrington
title	De novo design of a reversible phosphorylation-dependent switch for membrane targeting
title_short	De novo design of a reversible phosphorylation-dependent switch for membrane targeting
title_full	De novo design of a reversible phosphorylation-dependent switch for membrane targeting
title_fullStr	De novo design of a reversible phosphorylation-dependent switch for membrane targeting
title_full_unstemmed	De novo design of a reversible phosphorylation-dependent switch for membrane targeting
title_sort	de novo design of a reversible phosphorylation-dependent switch for membrane targeting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4376b19d20ae4edab075ab555f27de80
work_keys_str_mv	AT leonharrington denovodesignofareversiblephosphorylationdependentswitchformembranetargeting AT jordanmfletcher denovodesignofareversiblephosphorylationdependentswitchformembranetargeting AT tamaraheermann denovodesignofareversiblephosphorylationdependentswitchformembranetargeting AT dereknwoolfson denovodesignofareversiblephosphorylationdependentswitchformembranetargeting AT petraschwille denovodesignofareversiblephosphorylationdependentswitchformembranetargeting
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De novo design of a reversible phosphorylation-dependent switch for membrane targeting

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