De novo design of a reversible phosphorylation-dependent switch for membrane targeting
The ability to dynamically control protein-protein interactions and localization of proteins is critical in synthetic biological systems. Here the authors develop a peptide-based molecular switch that regulates dimer formation and lipid membrane targeting via reversible phosphorylation.
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Main Authors: | Leon Harrington, Jordan M. Fletcher, Tamara Heermann, Derek N. Woolfson, Petra Schwille |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2021
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Subjects: | |
Online Access: | https://doaj.org/article/4376b19d20ae4edab075ab555f27de80 |
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