Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin

The plasma membrane Ca2+ ATPase (PMCA) is essential for maintaining Ca2+ homeostasis in eukaryotic cells, and neuroplastin (NPTN) was recently identified as an obligatory subunit of PMCA. Here the authors present the cryo-EM structure of NPTN bound to human PMCA1, which reveals that the NPTN transme...

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Autores principales: Deshun Gong, Ximin Chi, Kang Ren, Gaoxingyu Huang, Gewei Zhou, Nieng Yan, Jianlin Lei, Qiang Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/437fde2f0eb24deca712b17fcd39f45e
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