Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin

The plasma membrane Ca2+ ATPase (PMCA) is essential for maintaining Ca2+ homeostasis in eukaryotic cells, and neuroplastin (NPTN) was recently identified as an obligatory subunit of PMCA. Here the authors present the cryo-EM structure of NPTN bound to human PMCA1, which reveals that the NPTN transme...

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Autores principales:	Deshun Gong, Ximin Chi, Kang Ren, Gaoxingyu Huang, Gewei Zhou, Nieng Yan, Jianlin Lei, Qiang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/437fde2f0eb24deca712b17fcd39f45e
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spelling	oai:doaj.org-article:437fde2f0eb24deca712b17fcd39f45e2021-12-02T17:31:30ZStructure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin10.1038/s41467-018-06075-72041-1723https://doaj.org/article/437fde2f0eb24deca712b17fcd39f45e2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06075-7https://doaj.org/toc/2041-1723The plasma membrane Ca2+ ATPase (PMCA) is essential for maintaining Ca2+ homeostasis in eukaryotic cells, and neuroplastin (NPTN) was recently identified as an obligatory subunit of PMCA. Here the authors present the cryo-EM structure of NPTN bound to human PMCA1, which reveals that the NPTN transmembrane (TM) helix interacts with TM10 and the TM8-9-linker of PMCA1.Deshun GongXimin ChiKang RenGaoxingyu HuangGewei ZhouNieng YanJianlin LeiQiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deshun Gong Ximin Chi Kang Ren Gaoxingyu Huang Gewei Zhou Nieng Yan Jianlin Lei Qiang Zhou Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
description	The plasma membrane Ca2+ ATPase (PMCA) is essential for maintaining Ca2+ homeostasis in eukaryotic cells, and neuroplastin (NPTN) was recently identified as an obligatory subunit of PMCA. Here the authors present the cryo-EM structure of NPTN bound to human PMCA1, which reveals that the NPTN transmembrane (TM) helix interacts with TM10 and the TM8-9-linker of PMCA1.
format	article
author	Deshun Gong Ximin Chi Kang Ren Gaoxingyu Huang Gewei Zhou Nieng Yan Jianlin Lei Qiang Zhou
author_facet	Deshun Gong Ximin Chi Kang Ren Gaoxingyu Huang Gewei Zhou Nieng Yan Jianlin Lei Qiang Zhou
author_sort	Deshun Gong
title	Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
title_short	Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
title_full	Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
title_fullStr	Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
title_full_unstemmed	Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin
title_sort	structure of the human plasma membrane ca2+-atpase 1 in complex with its obligatory subunit neuroplastin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/437fde2f0eb24deca712b17fcd39f45e
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Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin

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