Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs.

Parvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and specific interactions are key to control of host range. We show that several key mutations acquired by TfR during the evolution of Caniforms (dogs and related species) modified the interactions with parvovir...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jason T Kaelber, Ann Demogines, Carole E Harbison, Andrew B Allison, Laura B Goodman, Alicia N Ortega, Sara L Sawyer, Colin R Parrish
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
Sujets:
Accès en ligne:https://doaj.org/article/4383036ea106492a80544aa7e588178f
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!